RESUMO
Spinal chondrosarcoma are extremely rare and slowly growing tumors. They have been reported in thoraco-lumbar spine and lower cervical spine. Our case, a female, has a tumor located in the axis with extension into C3 and then caudally to C4 as the disease progressed. We present a technical innovation in spinal stabilization and compare our result with previously reported cases.
Assuntos
Vértebra Cervical Áxis/patologia , Vértebras Cervicais/patologia , Condrossarcoma/patologia , Neoplasias da Coluna Vertebral/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Vértebra Cervical Áxis/cirurgia , Braquiterapia , Vértebras Cervicais/cirurgia , Condrossarcoma/tratamento farmacológico , Condrossarcoma/radioterapia , Condrossarcoma/secundário , Condrossarcoma/cirurgia , Progressão da Doença , Doxorrubicina/administração & dosagem , Feminino , Humanos , Ifosfamida/administração & dosagem , Fixadores Internos , Metástase Linfática , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/radioterapia , Recidiva Local de Neoplasia/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X , Falha de TratamentoRESUMO
Los condrosarcomas espinales son tumores extremadamente raros y de crecimiento lento. Su principal localización es toraco-lumbar y cervical baja10. El caso que nosotros presentamos, una mujer, tiene un tumor localizado en la zona cervical alta C2 con extensión caudal a C3 y a lo largo de su evolución hasta C4 de predominio derecho. A pesar de haberse publicado con anterioridad1 aportamos nuevos aspectos de estabilidad cervical instrumentada y comparamos el resultado obtenido con las series publicadas
Spinal chodrosarcoma is extremely rare and slowly growing tumor. They have been reported in thoracolumbar spine and lower cervical spine10. Our case, a female, has a tumor located in the axis with extension into C3 and then caudally to C4 as the disease progressed. We present a technical innovation in spinal stabilization and compared our result with previously reported cases
Assuntos
Feminino , Pessoa de Meia-Idade , Humanos , Vértebra Cervical Áxis/patologia , Vértebras Cervicais/patologia , Condrossarcoma/patologia , Neoplasias da Coluna Vertebral/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Vértebra Cervical Áxis/cirurgia , Braquiterapia , Vértebras Cervicais/cirurgia , Condrossarcoma/tratamento farmacológico , Condrossarcoma/radioterapia , Condrossarcoma/secundário , Condrossarcoma/cirurgia , Progressão da Doença , Doxorrubicina/administração & dosagem , Ifosfamida/administração & dosagem , Fixadores Internos , Metástase Linfática , Tomografia Computadorizada por Raios X , Falha de Tratamento , Recidiva Local de Neoplasia/radioterapia , Recidiva Local de Neoplasia/cirurgia , Neoplasias da Coluna Vertebral/cirurgiaRESUMO
The clinical manifestations, surgical treatment and postoperative results of three patients with gangliocytomas of the cerebellum (Lhermitte-Duclos disease) are presented. Particular attention is placed in one of the cases, that of a young woman with a short clinical history of episodic symptoms of intracranial hypertension, dizziness and ataxia, with a concomitant frontal meningioma and in the general context of a multiple hamartoma syndrome (Cowden disease). The possible relationship between both diseases is contemplated, since they can be the extremes of a wide spectrum of a peculiar form of phakomatosis.
Assuntos
Neoplasias Cerebelares/diagnóstico , Ganglioneuroma/diagnóstico , Síndrome do Hamartoma Múltiplo/diagnóstico , Adulto , Neoplasias Cerebelares/patologia , Neoplasias Cerebelares/cirurgia , Feminino , Ganglioneuroma/patologia , Ganglioneuroma/cirurgia , Síndrome do Hamartoma Múltiplo/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
Calbindin D-28K and parvalbumin immunocytochemistry were used in the study of central ganglionic cell tumors. Most neurons in the ganglioglioma were immunoreactive to calbindin D-28K, but a few cells were labeled with antibodies against parvalbumin. In contrast, most cells in dysplastic gangliocytoma of the cerebellum were parvalbumin immunoreactive, but fewer reacted with anti-calbindin antibodies. These latter cells had two or three dendrites with claw-shaped terminals and axons with recurrent collateral branches and varicose terminals filled with strings and buttons. These observations suggest that central ganglionic cell tumors, including dysplastic gangliocytoma of the cerebellum, are composed of neurons which, on the basis of their calcium-binding protein content, have particular metabolic and electrophysiological properties.
